This small, compact, two-story house of cypress and brick was built in lower South Carolina by Paul de St. Julien on one of three land grants given his French Huguenot grandfather by the Lords Proprietors.
Many of the architectural features are uniquely French, the placement of the chimneys, the large squarish dormers, the beautiful trim work, the interior walls, and the gambrel roof.

Designated as the most architecturally significant structure in an area of Huguenot homes that were to be flooded when the Santee River was dammed in 1941, the house was taken apart and carefully reassembled on the Clemson University campus.

Hanover House was furnished with period antiques by the Spartanburg Committee of The National Society of The Colonial Dames of America in the State of South Carolina. "Of-the-period" lighting fixtures, given by the committee, have just been installed.

The house is the focal point of the historical site in The South Carolina Botanical Garden on the campus.